| 抗高血压药丁酸氯维地平的合成研究 |
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| 引用本文： | 赵华堂,杨艺虹,张秀兰,张珩,尹迪,王贝.抗高血压药丁酸氯维地平的合成研究[J].精细化工中间体,2013(5):26-29. |
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| 作者姓名： | 赵华堂 杨艺虹 张秀兰 张珩 尹迪 王贝 |
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| 作者单位： | 武汉工程大学绿色化工过程省部共建教育部重点实验室,湖北武汉430073 |
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| 基金项目： | 武汉工程大学青年科学基金项目（Q201203） |
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| 摘 要： | 以2,3-二氯苯甲醛和乙酰乙酸叔丁酯为原料,经Knoevenage反应、水解、缩合后与β-氨基巴豆酸甲酯环合得丁酸氯维地平。对反应物配比、催化剂、反应时间和温度等因素进行了研究,总收率达51.34%(以2,3-二氯苯甲醛计),其结构经IR、1H NMR和MS确证。
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| 关 键 词： | 抗高血压 氯维地平 合成 |
Synthesis of Clevidipine Butyrate |
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| ZHAO Hua-tang,YANG Yi-hong,ZHANG Xiu-lan,ZHANG Heng,YIN Di,WANG Bei.Synthesis of Clevidipine Butyrate[J].Fine Chemical Intermediates,2013(5):26-29. |
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| Authors: | ZHAO Hua-tang YANG Yi-hong ZHANG Xiu-lan ZHANG Heng YIN Di WANG Bei |
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| Affiliation: | (Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China) |
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| Abstract: | Clevidipine butyrate was synthesized starting from 2,3-dichloro-benzaldehyde and 3-oxo-butyric acid tert-butyl ester in five steps in an overall yield of 51.34%. The affecting factors including the ratio of the raw materials,the catalyst,the reaction time and the temperature were investigated. The structure was confirmed by IR,1H NMR and MS spectra. |
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| Keywords: | antihypertensive Clevidipine butyrate synthesis! |
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