| 乙氧基乙酰氯合成工艺研究 |
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| 引用本文： | 郭明,王光华,孙家隆.乙氧基乙酰氯合成工艺研究[J].精细化工中间体,2013(4):36-38. |
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| 作者姓名： | 郭明 王光华 孙家隆 |
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| 作者单位： | 青岛农业大学化学与药学院,山东青岛266109 |
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| 摘 要： | 以乙氧基乙酸为原料,氯化亚砜为酰化剂合成了纯度较高的乙氧基乙酰氯。并利用正交实验的方法对合成条件进行优化,获得优化工艺条件:n(氯化亚砜)∶n(乙氧基乙酸)=5∶1,催化剂为N,N-二甲基甲酰胺反应时间为16 h,收率达97.8%。
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| 关 键 词： | 氯化亚砜 乙氧基乙酸 乙氧基乙酰氯 |
Study on the Synthesis of Ethoxyacetyl Chloride |
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| GUO Ming,WANG Guang-hua,SUN Jia-long.Study on the Synthesis of Ethoxyacetyl Chloride[J].Fine Chemical Intermediates,2013(4):36-38. |
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| Authors: | GUO Ming WANG Guang-hua SUN Jia-long |
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| Affiliation: | ＊ (College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China) |
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| Abstract: | A high purity of ethoxyacetyl chloride was synthesized from ethoxyacetyl acid and thionyl chloride. Optimal reaction conditions were obtained based on orthogonal experiments that the molar ratio of thionyl chloride to ethoxyacetyl acid was 5 to 1, the catalyst was DMF and the reaction time was 16 h. |
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| Keywords: | thionyl chloride ethoxyacetyl acid ethoxyacetyl chloride |
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