| 新型生物降解交联剂的制备及其在壳聚糖交联膜中的应用 |
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| 引用本文： | 杨媛,李立华,容建华,周长忍. 新型生物降解交联剂的制备及其在壳聚糖交联膜中的应用[J]. 材料科学与工程学报, 2004, 22(2): 292-295 |
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| 作者姓名： | 杨媛 李立华 容建华 周长忍 |
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| 作者单位： | 暨南大学生命科学技术学院,广东,广州,510632 |
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| 基金项目： | 国家自然科学基金 , 广东省科技厅科技计划 |
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| 摘 要： | 本文用聚乙二醇和丙交酯在辛酸亚锡的催化作用下合成了可降解的二羟基中间体,再与2,4-甲苯二异氰酸酯(2,4-TDI)反应,合成了异氰酸酯基封端的一系列生物降解型交联剂.并且对中间体和交联剂进行了 FTIR分析表征.应用交联剂对壳聚糖膜材料进行交联,并对交联材料进行了吸水率,表面接触角及力学性能的测定,结果表明新型生物降解交联剂的运用不仪改善了材料吸水性,也提高了材料的力学性能.
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| 关 键 词： | 丙交酯 聚乙二醇 生物降解材料 交联剂 |
| 文章编号： | 1004-793X(2004)02-0292-04 |
| 修稿时间： | 2003-08-05 |
Preparation and Application of a Noval Biodegradable Cross-linker |
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| YANG Yuan,LI Li hua,RONG Jian hua,ZHOU Chang ren. Preparation and Application of a Noval Biodegradable Cross-linker[J]. Journal of Materials Science and Engineering, 2004, 22(2): 292-295 |
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| Authors: | YANG Yuan LI Li hua RONG Jian hua ZHOU Chang ren |
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| Abstract: | In this paper, a series of biodegradable cross linkers were made from 2,4 tolyene diisocyanate(2,4 TDI) and oligomers of poly(lactic acid) poly(ethylene glycol)(PLA PEG). The changing tendency of the oligomers's molecular weight was showed by intrinsic viscosity. The structures of PLA PEG oligomer and PLA PEG/PU biocross linker were studied by IR spectrum. These PLA PEG/PU were then used as cross linker to react with compounds with multi amido compounds or multi hydroxy groups. The as synthesised cross linked materials were characterized with water absorbency, surface contact angle and mechanics properties. The results showed that the hydrophilicy and mechanics properties of the cross linked materials were obviously improved. |
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| Keywords: | lactide poly(ethylene glycol) biodegradable material cross-linker |
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