红曲降血脂功能的研究及应用概况

红曲是以大米为原料,经红曲霉发酵而成的一种紫红色米曲,具有显著的降血脂功能。本文阐述了红曲与其他活性物质合理复配或根据中医原理与中药材复配具有很好的药理作用的研究;阐释了红曲降血脂功效大于纯洛伐他汀的原理,可能与红曲中各化合物协同作用、莫纳可林K的空间结构、口服生物药效率等有关;并阐述了红曲对有他汀不耐症的高血脂患者降血脂作用的研究,表明了红曲具有很好的耐受性;介绍了国内外红曲降血脂功能在保健食品上的应用,并对红曲中桔青霉素和红曲与其他药物相互作用这两个安全性问题的研究进展进行了总结,最后对今后红曲的发展方向进行了展望。 

Research and application progress of red yeast rice for lowering the blood chelosterol level

Red yeast rice (RYR) well-known for lowering the blood cholesterol level is produced through the fermentation of ordinary rice using monascus species. The research of RYR mixed with other active substances or Chinese herbal according to the traditional Chinese medicine was expounded. The potential reasons why the effect of RYR for lowering blood cholesterol was better than the pure lovastatin were illuminated, which were related to the compound synergistic effect, the spatial structure of monacolin K and oral bioavailability. The research of RYR for lowering blood chelosterol in staitin-intolerant patients was introduced. The application of RYR in functional food and the safety problems of RYR were summarized. At last, the future development trend and the prospects of RYR were related.