| 苋籽ACE抑制肽降血压的体外评价 |
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| 引用本文： | 周家华, 刘春英, 赵毅, 何计国, 陈飞平. 苋籽ACE抑制肽降血压的体外评价[J]. 食品工业科技, 2014, (08): 142-144. DOI: 10.13386/j.issn1002-0306.2014.08.023 |
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| 作者姓名： | 周家华 刘春英 赵毅 何计国 陈飞平 |
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| 摘 要： | 利用循证医学,依据血管紧张素转换酶(ACE)对血压的调节机理,以呋喃丙烯酰三肽(FAPGG)为血管紧张素Ⅰ模拟物,建立了胰蛋白酶模拟体外消化体系和大鼠肝脏混合功能氧化酶(MFO)模拟肝脏代谢体系,测得了未经处理的苋籽水解肽IC50值为1mg/mL,经过体外模拟消化和孵育处理后的苋籽水解肽IC50值为10mg/mL。
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| 关 键 词： | 苋籽 ACE抑制肽 降血压 评价 |
| 收稿时间： | 2013-08-01 |
In vitro evaluation of antihypertensive activity on ACE inhibitory peptides derived from Amaranth |
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| ZHOU Jia-hua, LIU Chun-ying, ZHAO Yi, HE Ji-guo, CHEN Fei-ping. In vitro evaluation of antihypertensive activity on ACE inhibitory peptides derived from Amaranth[J]. Science and Technology of Food Industry, 2014, (08): 142-144. DOI: 10.13386/j.issn1002-0306.2014.08.023 |
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| Authors: | ZHOU Jia-hua LIU Chun-ying ZHAO Yi HE Ji-guo CHEN Fei-ping |
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| Affiliation: | 1.Institute of Agricultural Integrated Development, Beijing Academy of Agricultural and Forestry Science;2.College of Food Science and Nutitional Engineering, China Agricultural University;3.Chinese Academy of Agricultural Engineering |
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| Abstract: | According to the angiotensin-converting enzyme (ACE) on blood pressure regulation mechanism, furan acryloyl tripeptide (FAPGG) as it was angiotensinⅠmimetic. It was established in vitro trypsin digestion system and simulated rat liver mixed function oxidase (MFO) analog liver metabolism system. Untreated ACE inhibitory peptides of amaranth IC50valued 1mg/mL, digestion and incubated in vitro after treatment ACE inhibitory peptides IC50 valued 10mg/mL. |
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| Keywords: | Amaranth ACE inhibitory peptides protein antihypertensive activity evaluation |
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