Partial-pKD1 plasmids provide enhanced structural stability for heterologous protein production in Kluyveromyces lactis |
| |
Authors: | HP Hsieh NA Da Silva |
| |
Affiliation: | Department of Medicine, Hospital, International Medical Center of Japan, Tokyo, Japan. |
| |
Abstract: | We describe a patient with leukocytosis with all the stages of neutrophilic series, peripheral dominant myeloblast proliferation, marked dysplasia of myeloid and erythroid series, and extramedullary hematopoiesis of the lymph nodes. A cytogenetic study of the bone marrow cells showed normal karyotype, and molecular analysis of the leukemic cells showed negative for BCR-ABL by RT-PCR. After chemotherapy, the patient went into complete remission with a normal blood and bone marrow profile with no dysplasia. On relapse, the hematological findings showed a typical bone marrow dominant acute myeloid leukemia, with the leukemic cells having a chromosomal abnormality. The patient exhibited the combined features of myeloproliferative disorder, myelodysplastic syndrome, peripheral dominant myeloblast proliferation (so-called peripheral leukemia) and typical acute myeloid leukemia throughout the clinical course. This is thought to be a rare overlapping disease involving these distinct hematological conditions that do not usually occur in the same patient. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|