Reduction of atherogenicity of natural fats by small additions of ethyl linoleate in the diet of the rat |
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Authors: | T C Hutsell F W Quackenbush |
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Affiliation: | (1) Department of Biochemistry, Purdue University, Lafayette, Indiana;(2) Present address: US Army Medical Research Unit, Presidio of San Francisco, Calif |
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Abstract: | Ethyl linoleate was substituted in part for the 20% of butterfat, hydrogenated coconut oil, lard, or tallow in an atherogenic
diet fed to rats throughout a 40-week experimental period. Aortic degeneration, evidenced by lipid infiltration of the intima,
was observed in the control groups but not in the linoleate-fed groups. Groups that received butterfat or hydrogenated coconut
oil showed reduced plasma and hepatic cholesterol levels when fed 2% of ethyl linoleate; groups that received lard or tallow
showed no significant change in plasma and hepatic cholesterol levels when fed 2% of ethyl linoleate; and groups that received
a fat-free diet with 2% of ethyl linoleate showed lower plasma and hepatic cholesterol levels and more complete aortic protection
than groups that were fed 20% of corn oil or cottonseed oil. The data suggest that, in the cholesterol-fed rat, the kind and
amount of dietary fatty esters may influence aortic condition via some route(s) other than control of plasma and hepatic cholesterol
levels.
Presented at the AOCS Meeting, Los Angeles, April 1966. Journal Paper No. 2952 of the Agricultural Experiment Station, Purdue
University, Lafayette, Ind. |
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