| 从红豆杉中提取紫杉醇的工艺研究 |
| |
| 引用本文： | 金洪顺,楼惠琴,蒋世春,白骅. 从红豆杉中提取紫杉醇的工艺研究[J]. 广州化工, 2014, 0(10): 88-91 |
| |
| 作者姓名： | 金洪顺 楼惠琴 蒋世春 白骅 |
| |
| 作者单位： | 浙江海正药业股份有限公司,浙江台州318000 |
| |
| 摘 要： | 紫杉醇(Taxol)是从红豆杉树皮中分离得到的一种二萜化合物,具有独特疗效的抗癌物,现已被多个国家批准应用于临床治疗卵巢癌和乳腺癌等疾病。由于红豆杉中的紫杉醇含量非常低(仅为0.010%~0.013%),而且大量结构类似的紫杉烷类物质存在,使得紫杉醇的分离纯化非常困难。本文通过对比5种不同提取方法 (液液萃取、固相萃取、硅胶层析、氧化铝层析、薄层层析),提出一种新的以氧化铝层析结合固相萃取工艺,具有紫杉醇高回收率的特点。
|
| 关 键 词： | 紫衫醇 红豆杉 提取 纯化 HPLC |
Study of Technology of Isolated Paclitaxel from Taxus Chinensis |
| |
| JIN Hong - shun,LOU Hui - qin,JIANG Shi - chun,BAI Hua. Study of Technology of Isolated Paclitaxel from Taxus Chinensis[J]. GuangZhou Chemical Industry and Technology, 2014, 0(10): 88-91 |
| |
| Authors: | JIN Hong - shun LOU Hui - qin JIANG Shi - chun BAI Hua |
| |
| Affiliation: | (Zhejiang Hisun Pharmaceutical Co. , Ltd. , Zhejiang Taizhou 318000, China) |
| |
| Abstract: | The antineoplastic agent paclitaxel （Taxol）, a diterpene- derivative isolated from Taxus chinensis Bark, was used in the treatment of ovarian cancer and/or breast cancer in many countries. Because of the trace amount of paclitaxel （only 0. 010% -0. 013% ） and a amount of similar structural taxanes in Taxus c. , paclitaxel was difficult to obtain from Taxus c.. A new high -paclitaxel -recovery process with Al2O3 chromatography -SPE process was presented by comparison of LLE, SPE, silica chromatography, Al2O3 chromatography, and TLC. |
| |
| Keywords: | paclitaxel Taxus chinensis extraction purification HPLC |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
