Metabolic disturbance of tryptophan-nicotinamide conversion pathway by putative endocrine disruptors, bisphenol A and styrene monomer |
| |
Authors: | Fukuwatari Tsutomu Toriochi Mai Ohta Mari Sasaki Ryuzo Shibata Katsumi |
| |
Affiliation: | Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture: 2500 Hassaka-cho, Hikone 522-8533, Japan. |
| |
Abstract: | Bisphenol A, a monomer of polycarbonate plastics, disturbed the conversion pathway of the amino acid tryptophan to the vitamin nicotinamide. The conversion ratio of tryptophan to nicotinamide was reduced to 1/15 by feeding a diet containing 1% bisphenol A. A putative disturbing reaction is kynurenine-->3-hydroxykynurenine, which is catalyzed by kynurenine monohydroxylase. This is an FAD-enzyme and requires NADPH as a coenzyme. Styrene monomer (1% addition to a normal diet) did not affect the food intake or the body weight, but slightly reduced the conversion ratio of tryptophan-nicotinamide. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|