| 壳聚糖/银复合纳米凝胶的制备及其抗肿瘤药物递送研究 |
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| 引用本文： | 周栋,刘赛男,孙争光,何培新,李玉林. 壳聚糖/银复合纳米凝胶的制备及其抗肿瘤药物递送研究[J]. 胶体与聚合物, 2020, 0(1): 21-24 |
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| 作者姓名： | 周栋 刘赛男 孙争光 何培新 李玉林 |
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| 作者单位： | 1.湖北大学化学化工学院;2.华东理工大学生物反应器工程国家重点实验室和超细材料教育部重点实验室 |
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| 基金项目： | 国家自然科学基金(81772317,51973060)。 |
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| 摘 要： | 本研究通过自组装技术将N,N’-双(丙烯酰)胱胺接枝到到纳米银粒子表面,得到双键修饰的纳米交联剂(bAG),然后采用双乳液法将bAG掺杂到壳聚糖纳米乳中,通过迈克尔加成反应使bAG表面双键与壳聚糖活性胺基原位交联形成掺杂纳米银的壳聚糖基纳米凝胶。该纳米凝胶可有效装载抗肿瘤药物阿霉素(包封率93%),所负载药物可在微酸性和还原性肿瘤微环境下实现响应性释放。
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| 关 键 词： | 纳米交联剂 纳米银 双乳法 纳米微球 药物递送 |
Preparation of Chitosan/Silver Hybrid Nanogels for Anticancer Drug Delivery |
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| ZHOU Dong,LIU Sai-nan,SUN Zheng-guang,HE Pei-xin,LI Yu-lin. Preparation of Chitosan/Silver Hybrid Nanogels for Anticancer Drug Delivery[J]. Chinese Journal of Colloid and Polymer, 2020, 0(1): 21-24 |
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| Authors: | ZHOU Dong LIU Sai-nan SUN Zheng-guang HE Pei-xin LI Yu-lin |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062;The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai 200237) |
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| Abstract: | A self-assembly technology was used to decorate silver nanoparticles with N, N’-bis(acryloyl)cystamine to offer a kind of double-bond modified nanocrosslinker, which was then used to in situ crosslink the chitosan nano-emulsion drops via a double emulsion method through Michael addition reaction between the bAG surface double bond and amino groups of chitosan. The resulting silver-doped nanogels can effectively carry the antitumor drug doxorubicin(encapsulation efficiency: 93%), which was able to be released in a sustainable way. Meanwhile, the nanocarriers showed a pH/redox dual-sensitivity in anticancer delivery under tumor-mimicking acidic and reductive microenvironments. |
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| Keywords: | Nano-crosslinker Silver Nanoparticles Double Emulsion Method Hybrid Nanogels Drug Delivery |
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