| 1-甲基-2-(2-羟基苯基)苯并咪唑新的合成法 |
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| 引用本文： | 李良萍,虞忠衡.1-甲基-2-(2-羟基苯基)苯并咪唑新的合成法[J].精细化工,1999,16(3):19-21. |
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| 作者姓名： | 李良萍 虞忠衡 |
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| 作者单位： | 中国科学院化学研究所,有机化学室,北京,100080 |
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| 摘 要： | 采用Ｎ 甲基邻苯二胺与水杨酰氯以质量比为１∶１．６４在吡啶溶剂中回流，得到中间体及关环产物，分离出的中间体再以吡啶作溶剂，吡啶盐酸盐作催化剂回流关环。两步粗品合并经酒精纯化，得到精品１ 甲基 ２ （２ 羟苯基）苯并咪唑，总收率为５４％，比文献法提高４０％左右。结构经１ＨＮＭＲ、ＭＳ及元素分析验证，同时阐述了可能的催化机理。
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| 关 键 词： | 1-甲基-2-（2-羟苯基）苯并咪唑 催化剂 合成 |
New Synthetic Method of 1-Methyl-2-(2-hydroxyphenyl) benzimidazole |
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| LI Liang-ping,YU Zhong-heng.New Synthetic Method of 1-Methyl-2-(2-hydroxyphenyl) benzimidazole[J].Fine Chemicals,1999,16(3):19-21. |
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| Authors: | LI Liang-ping YU Zhong-heng |
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| Abstract: | The 1methyl2(2hydroxyphenyl)benzimidazole() and the intermediate() are prepared by reaction N methyl o phenylenediamine with salicylyl chloride which the mass ratio is 11.64 with refluxing in pyridine and subsequent is separated from .The cyclization process is in progress by with catalyst of pyridine hydrochloride and pyridine with refluxing and the all crude products are purified by recrystallization from ethanol in 54% the tolal yield which is improved about 40% than that of references.The catalytic mechamism is proposed and the structures are proved by \ 1 HNMR and MS and elementary analysis.\= |
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| Keywords: | methyl2(2hydroxyphenyl)benzimidazole catalyst synthesis\= |
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