| X射线联合沙利度胺对胶质瘤U251细胞的抑制作用 |
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| 引用本文： | 孙美玲,于静萍,刘芬菊,刘海燕,杨辰.X射线联合沙利度胺对胶质瘤U251细胞的抑制作用[J].辐射研究与辐射工艺学报,2009,27(6). |
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| 作者姓名： | 孙美玲 于静萍 刘芬菊 刘海燕 杨辰 |
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| 作者单位： | 1. 苏州大学医学部放射医学与公共卫生学院,苏州,215123
2. 苏州大学医学部放射医学与公共卫生学院,苏州,215123;常州市第二人民医院,常州,213003 |
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| 基金项目： | 国家自然科学基金，常州市青年科技培养计划，常州市社会发展指导性项目 |
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| 摘 要： | 为探讨X射线联合沙利度胺对胶质瘤U251细胞的抑制作用,采用H~3-TdR掺入法和细胞克隆形成法检测沙利度胺增强U251细胞的辐射敏感性;细胞划痕实验观察沙利度胺抑制U251细胞的浸润能力.结果表明,沙利度胺能够抑制U251细胞浸润、DNA合成和克隆形成,与X射线联用后抑制作用增强,表现出协同作用.当细胞存活率为50%时,60 μg/mL、100 μg/mL 沙利度胺的辐射增敏系数为1.18和1.51.实验证明X射线联合沙利度胺能显著提高胶质瘤U251细胞的辐射敏感性,对U251细胞具有辐射增敏作用.
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| 关 键 词： | 沙利度胺 胶质瘤U251细胞 DNA合成 辐射敏感性 |
Inhibition of X-rays irradiation combined with thalidomide on glioma U251 cells |
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| SUN Meiling,YU Jingping,LIU Fenju,LIU Haiyan,YANG Chen.Inhibition of X-rays irradiation combined with thalidomide on glioma U251 cells[J].Journal of Radiation Research and Radiation Processing,2009,27(6). |
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| Authors: | SUN Meiling YU Jingping LIU Fenju LIU Haiyan YANG Chen |
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| Affiliation: | SUN Meiling1 YU Jingping1,2 LIU Fenju1 LIU Haiyan1 YANG Chen1 1 (College of Radiation Medicine and Public Health of Soochow University,Suzhou 215123,China) 2(Changzhou Second Hospital,Changzhou 213003,China) |
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| Abstract: | In order to investigate the inhibition effect of X-rays combined with thalidomide on glioma U251 cells, the cell scratch assay was used to detect the inhibition of thalidomide on U251 cells. And H3-TdR incorporation assay and colony formation were used to investigate the enhancement effect of thalidomide on the sensitivity of U251 cells to X-rays. It has been found that thalidomide has synergistic effect on therapy of glioma U251 cells if it is combined with X-rays irradiation as it can inhibit cells infilt... |
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| Keywords: | Thalidomide U251 cell DNA synthesis Radio-sensitivity |
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