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基于空洞U-Net网络的乳腺细胞图像分割算法
引用本文:唐浩漾,王燕,宋聪,张小媛. 基于空洞U-Net网络的乳腺细胞图像分割算法[J]. 光电子.激光, 2021, 32(5): 470-476
作者姓名:唐浩漾  王燕  宋聪  张小媛
作者单位:西安邮电大学自动化学院,陕西西安710121
基金项目:国家自然科学基金(21977082)、陕西省国际科技合作计划项目(2017KW-013) 、陕西省教育厅专项科技计划(18JK0702) 和西安市科技计划资助项目(201805040YD18CG24)资助项目 (西安邮电大学 自动化学院,陕西 西安 710121)
摘    要:乳腺细胞的准确分割是乳腺组织切片图像病理分析的关键环节,对乳腺癌的诊治具有重要价值.针对乳腺细胞图像分割中细胞边界不清晰、分割准确率低的问题,提出一种基于空洞U-Net网络的乳腺细胞图像分割算法.在U-Net网络中引入空洞卷积增大卷积层感受野,获得包含更多乳腺细胞边缘信息的特征图,在卷积层和池化层间增加实例归一化层,提...

关 键 词:乳腺细胞  图像分割  U-Net网络  空洞卷积  加权损失函数
收稿时间:2020-11-27

Breast cell image segmentation algorithm based on dilated U-Net network
TANG Hao-yang,WANG Yan,SONG Cong and ZHANG Xiao-yuan. Breast cell image segmentation algorithm based on dilated U-Net network[J]. Journal of Optoelectronics·laser, 2021, 32(5): 470-476
Authors:TANG Hao-yang  WANG Yan  SONG Cong  ZHANG Xiao-yuan
Abstract:Accurate segmentation of breast cells is the key link in the process o f pathological analysis of breast tissue section images,which has important va lue for the diagnosis and treatment of breast cancer.To solve the problems of u nclear cell boundary and low segmentation accuracy in breast cell image segmenta tion,an algorithm of breast cell image segmentation based on dilated U-Net net w ork is proposed.Dilated convolution is introduced into U-Net network to increa s e the receptive field of convolution layer to obtain the feature maps containing more breast cell boundary information.An instance normalization layer is added between the convolution layer and the pooling layer to improve the convergence speed of the network while alleviating the over fitting phenomenon.The weighted loss function is used to enhance the weight of breast cell region and improve t he ability of the network to extract cell features,so as to realize the effecti ve segmentation of breast cell boundaries.The experimental results on the USCB Breast dataset show that the segmentation accuracy and Dice coefficient of the p roposed algorithm are 97.63% and 83.25%,respectively,which are 6.5% and 6.6% h igher than that of the original U-Net network,and the segmentation effect is b etter for breast cell images.
Keywords:breast cell   image segmentation   U-Net network   dilated convolution   weighted loss function
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