Polyphenolic composition,antioxidant and antiproliferative effects of wild and cultivated blackberries (Rubus fruticosus L.) pomace |
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| Authors: | Miodrag Jazi? Zoran Kukri? Jelena Vuli? Dragana ?etojevi?-Simin |
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| Affiliation: | 1. Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia;2. Faculty of Technology, University of Banja Luka, Vojvode Stepe Stepanovi?a 75, 78000 Banja Luka, Bosnia and Herzegovina;3. Faculty of Medicine, Oncology Institute of Vojvodina, University of Novi Sad, Put Dr Goldmana 4, 21204 Sremska Kamenica, Serbia |
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| Abstract: | The content of total polyphenolics, antioxidative capacity and antiproliferative activity were tested in wild and cultivated blackberry pomace. Wild blackberry pomace extract Tw2 showed the highest following contents: total polyphenolics (50.16 mg GAE g?1 dw), flavonoids (7.73 mg Qc g?1 dw), flavonols (6.63 mg Qc g?1 dw) and total monomeric anthocyanins (13.40 mg Cy g?1). Tw2 extract significantly inhibited free radicals: IC50DPPH = 127.76 μg mL?1, IC50ABTS = 26.53 μg mL?1 and IC50 ˙ OH = 168.62 μg mL?1, and the growth of breast adenocarcinoma IC50MCF7 = 306.68 μg mL?1 and cervix epitheloid carcinoma cell lines IC50HeLa = 315.49 μg mL?1. Wild blackberry varieties had higher extraction yields, higher total polyphenolic contents and possessed stronger biological effects compared to cultivated blackberries (P < 0.05). All blackberry extracts showed high biological potential that could be attributed to high total polyphenols and flavonoids content and could be utilised as value-added functional food. |
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| Keywords: | Antioxidative capacity antiproliferative activity blackberry pomace polyphenols |
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