Constant Release Rate from Inert, Heterogeneous Matrixes by Means of Position-Dependent Loading |
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| Authors: | Todd P. Foster Eugene L. Parrott |
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| Affiliation: | a Drug Delivery Research and Development The Upjohn Co., Kalamazoo, MIb Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA |
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| Abstract: | Approximately zero-order release of ephedrine hydrochloride and procaine hydrochloride was obtained from multiple-layered matrixes of hydrogenated castor oil containing various concentrations of the medicinal compound in each layer. For the examples presented, an apparent zero-order release was observed for the release of 50-90% of the medicinal compound. |
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