| 猪去氧胆酸的纯化和杂质的结构鉴定 |
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| 引用本文： | 罗峰,邓启华,叶昌伦.猪去氧胆酸的纯化和杂质的结构鉴定[J].化学世界,2011,52(9):543-546. |
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| 作者姓名： | 罗峰 邓启华 叶昌伦 |
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| 作者单位： | 四川化工职业技术学院制药与环境工程系,四川泸州,646005 |
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| 摘 要： | 将猪去氧胆酸粗品形成甲酯,然后用苯结晶,分离出猪去氧胆酸甲酯,再利用NaOH的乙醇-水溶液进行水解,得到纯猪去氧胆酸；对猪去氧胆酸粗品中含有的主要杂质进行了结晶分离,通过IR,1H NMR,13C NMR,DEPT谱,HDMS,DSC/TGA和2D-NMR进行了结构鉴定,确定其主要杂质为猪胆酸.
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| 关 键 词： | 猪去氧胆酸 纯化 杂质 结构鉴定 |
Purification of Hyodeoxycholic Acid and Structural Identification of the Impurity |
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| LUO Feng,DENG Qi-hua,YE Chang-lun.Purification of Hyodeoxycholic Acid and Structural Identification of the Impurity[J].Chemical World,2011,52(9):543-546. |
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| Authors: | LUO Feng DENG Qi-hua YE Chang-lun |
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| Affiliation: | LUO Feng,DENG Qi-hua,YE Chang-lun(Department of Pharmaceutical and Environmental Engineering,Sichuan Chemical Vocation Technology College Sichuan Luzhou 646005,China) |
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| Abstract: | Methyl hyodeoxycholate was obtained from impure hyodeoxycholic acid,and it was crystallized in benzene.The pure methyl hyodeoxycholate was then hydrolyzed by sodium hydroxide in aqueous ethanol,and pure hyodeoxycholic acid was obtained.The major impurity was separated by column chromatography,and it was confirmed as hyocholic acid by means of IR,1H NMR,13C NMR,DEPT,HDMS,DSC/TGA,and 2D nuclear resonances. |
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| Keywords: | hyodeoxycholicy acid purification impurity structure confirmation |
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