| 2-氯-3-氟溴苯的合成 |
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| 引用本文： | 赵昊昱,潘玉琴. 2-氯-3-氟溴苯的合成[J]. 化学世界, 2011, 52(11): 678-680 |
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| 作者姓名： | 赵昊昱 潘玉琴 |
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| 作者单位： | 常州工程职业技术学院化工系,江苏常州,213164 |
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| 摘 要： | 以3-氯-2-氟苯胺为原料,经溴化和重氮化反应得到2-氯-3-氟溴苯,总摩尔产率约82.5％,纯度≥99 ％(GC).产物的结构通过MS及1 H NMR验证.其中,溴化反应一步合理的反应条件为:n(3-氯-2-氟苯胺)∶n(NBS)=1∶1.005,溴代时反应温度为10±2℃；重氮化反应条件为:n(4-溴-3-氯-2-...
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| 关 键 词： | 2-氯-3-氟溴苯 3-氯-2-氟苯胺 溴化 重氮化 |
Synthesis of 2-Chloro-3-fluorobromobenzene |
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| ZHAO Hao-yu,PAN Yu-qin. Synthesis of 2-Chloro-3-fluorobromobenzene[J]. Chemical World, 2011, 52(11): 678-680 |
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| Authors: | ZHAO Hao-yu PAN Yu-qin |
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| Affiliation: | ZHAO Hao-yu,PAN Yu-qin(Changzhou Institue of Engineering Technology,Department of Chemical Engineering,Jiangsu Changzhou 213164,China) |
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| Abstract: | 2-Chloro-3-fluorobromobenzene was synthesized from 3-chloro-2-fluoroaniline by bromization and diazotization with an overall yield of 82.5% and purity of 99.538%(GC).The structure of the product was confirmed by MS and 1H NMR.The optimized conditions of bromization were: n(3-chloro-2-fluoroaniline)∶n(NBS)= 1∶1.005,temperature at 10±2 ℃;The optimized conditions of diazotization were: n(4-bromo-3-chloro-2-fluoroaniline)∶n(NaNO2) = 1∶1.25,temperature at 80 ℃.The reaction conditions of this procees is mild,and it is suitable for production in industrial scale. |
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| Keywords: | 2-chloro-3-fluorobromobenzene 3-chloro-2-fluoroaniline bromization diazotization |
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