| 苦参碱衍生物的合成及抗肿瘤活性测试 |
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| 引用本文： | 何黎琴,黄鹏,王效山. 苦参碱衍生物的合成及抗肿瘤活性测试[J]. 化学世界, 2011, 52(9): 523-525 |
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| 作者姓名： | 何黎琴 黄鹏 王效山 |
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| 作者单位： | 安徽中医学院药学院,安徽省现代中药重点实验室,安徽合肥230031 |
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| 基金项目： | 安徽省优秀青年人才基金(2009SQRZ113) |
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| 摘 要： | 以苦参碱为原料合成去氧苦参碱和苦参酸.其结构经EI-MS、1H NMR、IR和元素分析确证.采用MTT法测试所合成化合物的体外抗肿瘤活性,结果表明,去氧苦参碱抗肝癌细胞HepG2和SMMC7721的活性强于苦参碱.
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| 关 键 词： | 苦参碱 去氧苦参碱 苦参酸 抗肿瘤 |
Synthesis and Biological Evaluation of Matrine Derivatives as Anticancer Agents |
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| HE Li-qin,HUANG Peng,WANG Xiao-shan. Synthesis and Biological Evaluation of Matrine Derivatives as Anticancer Agents[J]. Chemical World, 2011, 52(9): 523-525 |
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| Authors: | HE Li-qin HUANG Peng WANG Xiao-shan |
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| Affiliation: | HE Li-qin,HUANG Peng,WANG Xiao-shan(Anhui Traditional Chinese Medicine College,Anhui Key Laboratory of Modernized Chinese Material Medical,Anhui Hefei 230031,China) |
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| Abstract: | Two matrine derivatives were synthesized,their structures were confirmed by MS,IR,and 1H NMR spectra.The biological evaluation showed that compound deoxy-matrine had stronger cytotoxic activities than maitrine against human hepatoma cells(Hep G2 and SMMC 7721) in vitro by MTT method. |
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| Keywords: | matrine deoxy-matrine matrinic acid anti-cancer |
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