| Baylis-Hillman加成物的合成及生物活性研究 |
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| 引用本文： | 杨桂秋,于春睿,于秀兰,仇兴华.Baylis-Hillman加成物的合成及生物活性研究[J].化学试剂,2011(9):803-806. |
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| 作者姓名： | 杨桂秋 于春睿 于秀兰 仇兴华 |
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| 作者单位： | 沈阳化工大学制药工程系;沈阳化工研究院; |
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| 基金项目： | 辽宁省高等学校科学研究立项计划资助项目(2008560); 沈阳化工大学博士启动基金资助项目(200809) |
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| 摘 要： | 以三甲胺、1,4-重氮二环2,2,2]辛烷(DABCO)为催化剂,室温合成了19个Baylis-Hillman加成物(BH),生物活性测试发现:在2000g a.i./ha的剂量下,2-((2,4-二氯苯基)(羟基)甲基)丙烯酸甲酯(BH-7)具有较为广谱的除草活性,对阔叶杂草百日草和苘麻的防效达到100％;对禾本科...
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| 关 键 词： | Baylis-Hillman加成物 合成 生物活性 |
Synthesis and bioactivity Baylis-Hillman adducts |
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| YANG Gui-qiu,YU Chun-rui,YU Xiu-lan,QIU Xing-hua.Synthesis and bioactivity Baylis-Hillman adducts[J].Chemical Reagents,2011(9):803-806. |
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| Authors: | YANG Gui-qiu YU Chun-rui YU Xiu-lan QIU Xing-hua |
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| Affiliation: | YANG Gui-qiu1,YU Chun-rui2,YU Xiu-lan1,QIU Xing-hua1(1.Department of Pharmaceutical Engineering,Shenyang University of Chemical Technology,Shenyang 110142,China,2.Shenyang Research Institute of Chemical Industry,Shenyang 110021,China) |
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| Abstract: | Nineteen Baylis-Hillman adducts(BH) were synthesized at room temperature using trimethylamine or 1,4-diaza-bicyclooctane(DABCO) as catalyst.Biological activity evaluations showed that methyl 2-((2,4-dichlorophenyl)(hydroxy) methyl)acrylate(BH-7) exhibited broad-spectrum herbicidal activity,with 100% control of broad-leaved weeds Zinnia elegans Jacq.(YOA) and Abutilon theophrasti Medic(VEL),80% and 75% control of grass weeds Echinochloa crusgalli(L.) Baeuv(BYG) and Digitaria sanguinalis(L.)Scop(CRG)at 2000 g... |
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| Keywords: | Baylis-Hillman adduct synthesis biological activity |
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