| 双对二甲氨基苯甲醛缩1,4-二(3-氨基丙基)哌嗪希夫碱的合成工艺及抑菌活性研究 |
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| 引用本文： | 张娜,沈红光,李光辉,王颖,许瑞波.双对二甲氨基苯甲醛缩1,4-二(3-氨基丙基)哌嗪希夫碱的合成工艺及抑菌活性研究[J].化学世界,2011,52(10):623-625. |
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| 作者姓名： | 张娜 沈红光 李光辉 王颖 许瑞波 |
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| 作者单位： | 淮海工学院化学工程学院,江苏连云港,222005 |
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| 基金项目： | 江苏省青蓝工程优秀青年骨干教师资助项目(苏教师[2008]16) |
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| 摘 要： | 以对二甲氨基苯甲醛(DMAB)和1,4-二(3-氨基丙基)哌嗪(BAPP)为原料,通过缩合反应合成了一个新的DMAB-BAPP希夫碱.利用正交试验确定了最佳合成工艺条件,即反应温度50℃,反应时间4h,DMAB与BAPP投料摩尔比是2.1∶1,在此条件下,产物收率为83.7％.通过琼脂扩散法测定了产物的抑菌性能,结果表...
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| 关 键 词： | 对二甲氨基苯甲醛 1 4-二(3-氨基丙基)哌嗪 希夫碱 合成工艺 抑菌活性 |
Synthesis and Antibacterial Activity of A New Schiff Base Bis(4-dimethylaminobenzaldehyde)-[1,4-bis(3-aminopropyl) piperazine] |
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| ZHANG Na,SHEN Hong-guang,LI Guang-hui,WANG Ying,XU Rui-bo.Synthesis and Antibacterial Activity of A New Schiff Base Bis(4-dimethylaminobenzaldehyde)-[1,4-bis(3-aminopropyl) piperazine][J].Chemical World,2011,52(10):623-625. |
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| Authors: | ZHANG Na SHEN Hong-guang LI Guang-hui WANG Ying XU Rui-bo |
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| Affiliation: | ZHANG Na,SHEN Hong-guang,LI Guang-hui,WANG Ying,XU Rui-bo(School of Chemical Engineering,Huaihai Institute of Technology,Jiangsu Lianyungang 222005,China) |
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| Abstract: | A new Schiff base bis(4-dimethylaminobenzaldehyde)-1,4-bis(3-aminopropyl)piperazine] was synthesized by the condensation reaction of 4-dimethylaminobenzaldehyde and 1,4-bis(3-aminopropyl)-piperazine.The optimal synthetic conditions obtained by orthogonal experiment were as follows: reaction temperature of 50℃,reaction time of 4 h,and the mole ratio 4-dimethylaminobenzaldehyde to 1,4-bis(3-aminopropyl)piperazine of 2.1∶1.The yield of the title product was about 83.7%.The antibacterial activity was investigated by agar diffusion method,and the results indicated that the Schiff base was active against Staphyloccus aureus,Escherichia coli and Bacillus subtilis. |
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| Keywords: | 4-dimethylaminobenzaldehyde 1 4-bis(3-aminopropyl)piperazine Schiff base synthesis antibacterial activity |
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