| 1H-吡唑[3,4-b]吡啶的合成研究 |
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| 引用本文： | 黄斌,张征林. 1H-吡唑[3,4-b]吡啶的合成研究[J]. 化学试剂, 2011, 0(9): 841-842,864 |
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| 作者姓名： | 黄斌 张征林 |
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| 作者单位： | 东南大学成贤学院;东南大学化学化工学院; |
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| 摘 要： | 以2-氯烟酸为起始原料,经过还原、氧化、肟化及环合反应合成了标题化合物,4步反应总收率67.21％.产品经1HNMR和质谱表征.该方法具有操作简单、成本低、环境友好等优点,适合工业化生产.
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| 关 键 词： | 2-氯烟酸 还原 氧化 肟化 环合 IH-吡唑[3,4-b]吡啶 |
Synthesis of 1H-pyrazolo[3,4-b] pyridine |
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| HUANG Bina,ZHANG Zheng-linb. Synthesis of 1H-pyrazolo[3,4-b] pyridine[J]. Chemical Reagents, 2011, 0(9): 841-842,864 |
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| Authors: | HUANG Bina ZHANG Zheng-linb |
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| Affiliation: | HUANG Bina,ZHANG Zheng-linb(a.Department of Chemical and Pharmaceutical Engineering of Southeast University Chengxian College,b.School of Chemistry and Chemical Engineering,Southeast University,Nanjing 210088,China) |
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| Abstract: | 1H-Pyrazolo[3,4-b] pyridine was synthesized by using 2-chloronicotinic acid as the starting material via reduction,oxidation,oximation and cyclization.The total yield of four steps was 67.21%.The structure of the product was confirmed by 1HNMR,and MS.This method has many advantages,such as easy operation,low cost and environment-friendly,which can be feasible to large scale preparation. |
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| Keywords: | 2-chloronicotinic acid reduction oxidation oximation cyclization 1H-pyrazolo[3 4-b] pyridine |
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