| 具有NO释放作用的芒柄花素衍生物的合成与表征 |
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| 引用本文： | 李芳耀,杨新平,黄兰,林家逊,韦静.具有NO释放作用的芒柄花素衍生物的合成与表征[J].化学试剂,2011,33(10):958-960. |
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| 作者姓名： | 李芳耀 杨新平 黄兰 林家逊 韦静 |
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| 作者单位： | 1. 桂林医学院药学院,广西桂林,541004
2. 桂林医学院研究生学院,广西桂林,541004 |
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| 基金项目： | 桂林医学院青年教师科研启动基金资助项目 |
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| 摘 要： | 以间苯二酚和对甲氧基苯乙酸为原料,三氟化硼-乙醚为催化剂,采用超声波辐射技术合成了芒柄花素,将有机硝酸酯通过不同长度的碳链与芒柄花素7-酚羟基连接,得到两个具有NO释放作用的芒柄花素衍生物,其结构经IR、1HNMR、MS及元素分析表征.
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| 关 键 词： | 芒柄花素 NO供体 衍生物 合成 |
Synthesis and characterization of formononetin derivatives with NO releasing function |
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| LI Fang-yao,YANG Xin-ping,HUANG Lan,LIN Jia-xun,WEI Jing.Synthesis and characterization of formononetin derivatives with NO releasing function[J].Chemical Reagents,2011,33(10):958-960. |
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| Authors: | LI Fang-yao YANG Xin-ping HUANG Lan LIN Jia-xun WEI Jing |
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| Affiliation: | LI Fang-yaoa,YANG Xin-pinga,HUANG Lana,LIN Jia-xuna,WEI Jingb (Guilin Medical College,a.School of Pharmacy,b.School of Graduate,Guilin 541004,China) |
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| Abstract: | Formononetin was synthesized from resorcinol and p-methoxyphenylacetic acid using boron-etherate as catalyst under ultrasonic irradiation.The nitrate was linked to the 7-OH directly to give two novel formononetin derivatives with releasing NO function.The target compounds were characterized by IR,1HNMR,MS and elemental analysis. |
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| Keywords: | formononetin NO donor derivatives synthesis |
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