| 5-甲基吡嗪-2-羧酸的合成 |
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| 引用本文： | 谢婷,陈文华. 5-甲基吡嗪-2-羧酸的合成[J]. 化学试剂, 2011, 0(9): 849-851 |
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| 作者姓名： | 谢婷 陈文华 |
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| 作者单位： | 常州工程职业技术学院制药系; |
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| 摘 要： | 以异丙醇胺为原料,经环合制得2,5-二甲基吡嗪,再以醋酸钴、醋酸锰作催化剂,溴化钾作助催化剂下催化氧化制得标题化合物,总收率68％.
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| 关 键 词： | 异丙醇胺 2,5-二甲基吡嗪 5-甲基吡嗪-2-羧酸 |
Synthesis of 5-methylpyrazine-2-carboxylic acid |
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| XIE Ting,CHEN Wen-hua. Synthesis of 5-methylpyrazine-2-carboxylic acid[J]. Chemical Reagents, 2011, 0(9): 849-851 |
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| Authors: | XIE Ting CHEN Wen-hua |
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| Affiliation: | XIE Ting,CHEN Wen-hua(Department of Pharmaceutical Engineering,Changzhou Vocation College of Engineering and Technology,Changzhou 213164,China) |
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| Abstract: | 5-Methylpyrazine-2-carboxylic acid was synthesized starting from isopropanolamine,which was prepared from isopropanolamine by condensation reaction,follow by oxidation with air in the presence of Co(Ac)2/Mn(Ac)2/KBr.The over yiled was 68%. |
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| Keywords: | isopropanolamine 2 5-dimethylpyrazine 5-methylpyrazine-2-carboxylic acid |
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