| 微波法合成香豆素-3-羧酸乙酯的工艺研究 |
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| 引用本文： | 涂永元,邱飞.微波法合成香豆素-3-羧酸乙酯的工艺研究[J].化学世界,2011,52(12):731-733. |
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| 作者姓名： | 涂永元 邱飞 |
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| 作者单位： | 华侨大学分子药物学研究所,福建泉州362021;分子药物教育部工程研究中心福建泉州362021 |
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| 基金项目： | 福建省自然科学基金项目(2009J05029); 福建省生物医药工程研究生教育创新基地项目(06070205) |
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| 摘 要： | 以水杨醛、丙二酸二乙酯为原料,二乙胺为催化剂,采用微波辐射技术合成香豆素-3-羧酸乙酯,利用正交实验设计考察了微波功率、原料配比、催化剂用量、辐射时间、溶剂用量对产物产率的影响.结果表明,当摩尔比水杨醛:丙二酸二乙酯:二乙胺=1∶1.3∶0.3时,5 mL乙醇,采用600 W微波辐射4 min,香豆素-3-羧酸乙酯产率...
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| 关 键 词： | 香豆素-3-羧酸乙酯 微波辐射 正交设计 |
Study on Synthesis of Ethyl Coumarin-3-carboxylateunder Microwave Irradiation |
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| TU Yong-yuan,QIU Fei.Study on Synthesis of Ethyl Coumarin-3-carboxylateunder Microwave Irradiation[J].Chemical World,2011,52(12):731-733. |
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| Authors: | TU Yong-yuan QIU Fei |
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| Affiliation: | TU Yong-yuan1,2,QIU Fei1,2(1.Institute of Molecular Medicine,Huaqiao University,Fujian Quanzhou 362021,China,2.Engineering Research Center of Molecular Medicine,Ministry of Education,China) |
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| Abstract: | Ethyl coumarin-3-carboxylate was synthesized from salicylaldehyde and diethyl malonate using diethylamine as catalyst promoted by microwave irradiation.The effect of microwave power,ratio of reagents,contents of catalyst,microwave irradiation time and amount of solvent on the yield was to investigated by orthogonal design method.When the molar raio of salicylaldehyde∶diethyl malonate∶diethylamine =1∶1.3∶0.3,the irradiation time of 600W was 4 min and 5mL ethanol was used,the yield of ethyl coumarin-3-carboxylate was 88.8%. |
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| Keywords: | ethyl coumarin-3-carboxylate microwave irradiation orthogonal design |
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