2,6-二甲基吡喃酮的合成

以乙酰丙酮和乙酸甲酯为原料,四氢呋喃为溶剂,乙醇钠为催化剂,进行克莱森缩合反应合成2,6-二甲基吡喃酮。通过单因素实验考察了影响2,6-二甲基吡喃酮合成的各项因素。结果表明,当n(乙酰丙酮)∶n(乙酸甲酯)∶n(乙醇钠)=1.0∶2.5∶2.0、反应温度为85℃、反应时间为6 h时,以乙酰丙酮计的2,6-二甲基吡喃酮收率可达13.32%,经HPLC测定其色谱纯度为95.37%。

Study on synthesis of 2,6-dimethyl-gamma-pyrone

2,6-Dimethyl-γ-pyrone was synthesized via the Claisen condensation with acetylacetone and methyl acetate as raw materials,tetrahydrofuran as solvent,sodium ethylate as catalyst.The effect of reaction conditions on the properties of 2,6-dimethyl-γ-pyrone was investigated by method of single factor experiments.The results show that the yield of 2,6-dimethyl-γ-pyrone could reach 13.32% and its content was 95.37% calculated by acetylacetone under the following reaction conditions: the molar ratio of acetylacetone to methyl acetate and sodium ethylate was 1.0∶ 2.5∶ 2.0,the reaction temperature was 85 ℃,and the reaction time was 6 hours.