| 2-氯-6-甲氧基-9-烷基嘌呤化合物的合成 |
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| 引用本文： | 冯西平,张宏,范跃芳,武鼎铭,陆鸿飞. 2-氯-6-甲氧基-9-烷基嘌呤化合物的合成[J]. 精细化工, 2011, 28(10): 991-994 |
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| 作者姓名： | 冯西平 张宏 范跃芳 武鼎铭 陆鸿飞 |
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| 作者单位： | 1. 四川化工职业技术学院化学工程系,四川 泸州,646005
2. 江苏科技大学生物与化学工程学院,江苏 镇江,212003 |
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| 摘 要： | 以2-氨基-6-氯嘌呤为原料,通过烃基化反应、重氮化反应和烷氧基化反应,得到2-氯-6-甲氧基-9-烷基嘌呤化合物,其结构经MS、1HNMR和元素分析等方法确认。探讨了溶剂选择、原料配比、催化剂和反应温度等因素对N9-烃基化反应的影响,其最优反应条件为:以DMF为溶剂,碳酸钾为缚酸剂,苄基三乙基氯化铵为相转移催化剂,n(2-氨基-6-氯嘌呤)∶n(溴代烷)=1∶3,n(溴代烷)∶n(碳酸钾)=1∶1.5,与碳酸钾等物质的量的苄基三乙基氯化铵,反应温度为20℃,烃基化反应收率可达76%以上。
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| 关 键 词： | 嘌呤化合物 烃基化 重氮化 烷氧基化 医药与日化原料 |
| 收稿时间： | 2011-05-24 |
| 修稿时间： | 2011-08-13 |
Synthesis of 2-Chloro-6-methoxy-9-alkylpurine Compounds |
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| FENG Xi-ping,ZHANG Hong,FAN Yue-fang,WU Ding-ming and LU Hong-fei. Synthesis of 2-Chloro-6-methoxy-9-alkylpurine Compounds[J]. Fine Chemicals, 2011, 28(10): 991-994 |
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| Authors: | FENG Xi-ping ZHANG Hong FAN Yue-fang WU Ding-ming LU Hong-fei |
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| Affiliation: | Department of Chemical Engineering, Sichuan Chemical Technology College,department of basic courses, Sichuan Chemical Technology College,,School of Biological and Chemical Engineering, Jiangsu University of Science and Technology,School of Biological and Chemical Engineering, Jiangsu University of Science and Technology |
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| Abstract: | An efficient procedure for the synthesis of 2-chloro-6-methoxy-9-alkylpurine compounds with better yield through alkylation,diazotization and oxyalkylation of 2-amino-6-chloropurine is reported.The target compounds were characterized by means of MS,1HNMR and elemental analysis.The effect of solvent,mole ratio of raw material,catalyst and reaction temperature on the alkylation reaction was discussed,and the yield of the target compounds was more than 76% under the following optimized conditions:n(2-amino-6-c... |
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| Keywords: | purine compounds alkylation diazotization oxyalkylation synthesis |
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