| 泰妥拉唑的合成及表征 |
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| 引用本文： | 阎峰,迟骋,樊凯奇,李晶,关瑾. 泰妥拉唑的合成及表征[J]. 精细化工, 2011, 28(6): 609-611 |
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| 作者姓名： | 阎峰 迟骋 樊凯奇 李晶 关瑾 |
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| 作者单位： | 沈阳化工大学应用化学学院,辽宁沈阳,110142 |
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| 基金项目： | 辽宁省自然科学基金资助（20092055） |
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| 摘 要： | 以2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐(Ⅱ)和2-巯基-5-甲氧基咪唑并[4,5-b]吡啶(Ⅲ)为原料,在氢氧化钠水溶液中于30℃反应生成2-[2-(4-甲氧基-3,5-二甲基)吡啶甲硫基]-5-甲氧基咪唑[4,5-b]吡啶(Ⅳ),收率90.1%。随后用质量分数为30%的过氧化氢氧化制得泰妥拉唑(Ⅰ),收率86.3%,两步总收率为77.8%。产物结构经IR、1HNMR确证。
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| 关 键 词： | 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐 2-巯基-5-甲氧基咪唑并[4,5-b]吡啶 泰妥拉唑 精细化工中间体 |
| 收稿时间： | 2011-03-07 |
| 修稿时间： | 2011-03-23 |
Synthesis and Characterization of Tenatoprazole |
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| YAN Feng,CHI Cheng,FAN Kai-qi,LI Jing and GUAN Jin. Synthesis and Characterization of Tenatoprazole[J]. Fine Chemicals, 2011, 28(6): 609-611 |
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| Authors: | YAN Feng CHI Cheng FAN Kai-qi LI Jing GUAN Jin |
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| Affiliation: | Applied Chemistry College, Shenyang University of Chemical Technology,Applied Chemistry College, Shenyang University of Chemical Technology,Applied Chemistry College, Shenyang University of Chemical Technology,Applied Chemistry College, Shenyang University of Chemical Technology, Shenyang |
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| Abstract: | 2-[2-(4-Methoxy-3,5-dimethyl) pyridlmethylthio]-5-methoxyimidazo pyridine(Ⅳ) was prepared through the reaction of 2-chloromethyl-4-methoxy-3,5-dimethyl pyridine hydrochloride(Ⅱ) with 2-mercapto-5-methoxyimidazopyridine(Ⅲ) in the solution of sodium hydroxide at 30 ℃,and the yield reached 90.1%.Subsequently,the oxidation of sulfide Ⅲ with hydrogen peroxide of the mass fraction of 30% afforded the target compound tenatoprazole(Ⅰ).The yield reached 86.3%.The overall yield reached 77.8%.The structure of the target product was characterized and confirmed by means of IR,1HNMR. |
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| Keywords: | 2-Chloromethyl-3,5-dimethyl-4-nitropyridine 2-mercapto-5-methoxyimidazo[4,5-b] pyridine Tenatoprazole |
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