催化加氢合成对甲氧基苯甲醇工艺优化

研究了以对甲氧基苯甲醛为底物,通过Pd/C催化氢化合成对甲氧基苯甲醇的工艺。考察了不同溶剂,反应压力,催化剂用量,底物浓度,反应温度,反应时间及催化剂重复使用诸因素对产物对甲氧基苯甲醇收率或产物组成的影响。结果表明:以200mL乙醇为溶剂,原料为0.4mol,5%Pd/C用量为5%(质量分数),反应压力为0.3MPa,反应温度为30℃,反应时间为8h时,经过过滤,常压蒸馏、减压蒸馏,得无色透明的对甲氧基苯甲醇液体,收率可接近95%。

Process Optimization of Synthesizing p-Methoxybenzyl-alcohol by Catalytic Hydrogenation

A method to synthesis p-methoxybenzyl alcohol by reacting p-methoxybenzaldehyde with pd/C catalyst was studied.The effects of reactions conditions such as kinds of solvent,reaction pressure,amount of catalyst,concentration of reactant,reaction temperature,reaction time and reuse of catalyst on yield of p-methoxybenzyl alcohol and product composition were investigated.The results showed that the optimum conditions were as follows: ethanol solvent was 200 mL,reactant was 0.4 mol,amount of 5%Pd/C catalyst was 5%(mass fraction),reaction pressure was 0.3 MPa,reaction temperature was 30℃,reaction time was 8 h.After filtration,normal pressure distillation and reduced pressure distillation,a colorless and transparent liquid of p-methoxybenzyl alcohol was obtained,and the yield was close to 95%.