| 3-(2-对甲苯基苯并呋喃-3-基)环己-2-烯酮的合成 |
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| 引用本文： | 唐建生,莫敏,郑敏.3-(2-对甲苯基苯并呋喃-3-基)环己-2-烯酮的合成[J].化学世界,2013,54(3):169-171,192. |
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| 作者姓名： | 唐建生 莫敏 郑敏 |
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| 作者单位： | 湖南第一师范学院数理系,湖南长沙,410205 |
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| 基金项目： | 湖南省教育厅科研项目，湖南省科技厅科技项目 |
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| 摘 要： | 以N,N-二甲基甲酰胺作溶剂,2-对甲苯乙炔基苯酚和α-环己烯酮在氯化钯和四丁基碘化铵的作用下,可以顺利发生分子内环化反应一步合成3-(2-对甲苯基苯并呋喃-3-基)环己-2-烯酮。反应最佳条件为:n(2-对甲苯乙炔基苯酚)∶n(α-环己烯酮)∶n(氯化钯)∶n(四丁基碘化铵)=1∶5∶0.05∶1,反应温度为100℃,反应时间为24h,反应最佳产率82.0%。产物经1 H NMR、13 CNMR和GC-MS确征。
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| 关 键 词： | 氯化钯 四丁基碘化铵 串联反应 3-(2-对甲苯基苯并呋喃-3-基)环己-2-烯酮 |
Synthesis of 3-(2-p-Tolylbenzofuran-3-yl) cyclohex-2-enone |
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| TANG Jian-sheng,MO Min,ZHENG Min.Synthesis of 3-(2-p-Tolylbenzofuran-3-yl) cyclohex-2-enone[J].Chemical World,2013,54(3):169-171,192. |
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| Authors: | TANG Jian-sheng MO Min ZHENG Min |
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| Affiliation: | (Mathematics and Science Department,Hunan First Normal University,Hunan Changsha 410205,China) |
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| Abstract: | 3-(2-p-Tolylbenzofuran-3-yl)cyclohex-2-enone was synthesized by the reaction of 2-(p-tolylethynyl)phenol and cyclohex-2-enone in the presence of palladium(Ⅱ) chloride and tetrabutyl ammonium iodide as catalysts via a tandem reaction in N,N-dimethylformamide solvent.The optimum reaction conditions were as follows: n(2-(p-tolylethynyl)phenol)∶n(cyclohex-2-enone)∶n(PdCl2)∶n(Bu4NI)=1∶5∶0.05∶1 and reacting under air atmosphere at 100℃ for 24 h.The yield was 82%.The structure was characterized by 1H NMR,13C NMR and GC-MS. |
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| Keywords: | palladium(Ⅱ) chloride tetrabutyl ammonium iodide cascade reaction 3-(2-p-tolylbenzofuran-3-yl)cyclohex-2-enone |
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