| GC-MS/MS分析化妆品中的防腐剂 |
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| 引用本文： | 田玉平,李杰,吴建军,顾玲玲.GC-MS/MS分析化妆品中的防腐剂[J].化学世界,2013,54(5):279-281,310,314. |
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| 作者姓名： | 田玉平 李杰 吴建军 顾玲玲 |
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| 作者单位： | 上海市计量测试技术研究院,上海,201203 |
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| 基金项目： | 上海市技术性贸易措施应对专项，国家质量监督检验检疫总局 |
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| 摘 要： | 建立了化妆品中防腐剂:苯甲醇、苯氧乙醇、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯的GC-MS/MS分析方法。化妆品样品经异丙醇超声波萃取,除去水分后,DB-5MS(30m×0.32mm×0.25μm)毛细管色谱柱分离,多反应监测(MRM)的扫描方式定性、定量测定。苯甲醇、苯氧乙醇、对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯的检测限分别为:0.05μg/g,0.02μg/g,0.01μg/g,0.01μg/g,0.01μg/g,0.01μg/g,相对标准偏差<8%,0.5μg/g的加标回收率为:86.8%～113.7%,线性范围为:0.1～10μg/g,线性相关系数>0.993。
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| 关 键 词： | GC-MS/MS 防腐剂 化妆品 |
Simultaneous Testing Preservatives in Cosmetics by GC-MS/MS |
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| Tian Yu-ping,LI Jie,WU Jian-jun,GU Ling-ling.Simultaneous Testing Preservatives in Cosmetics by GC-MS/MS[J].Chemical World,2013,54(5):279-281,310,314. |
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| Authors: | Tian Yu-ping LI Jie WU Jian-jun GU Ling-ling |
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| Affiliation: | (Shanghai Institute of Measurement and Testing Technology,Shanghai 201203,China) |
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| Abstract: | A method was established for simultaneous determination of preservatives in cosmetics samples,including benzyl alcohol,2-phenoxy ethanol,methyl 4-hydroxybenzoate,ethyl 4-hydroxybenzoate,propyl 4-hydroxybenzoate and 4-(butoxycarbonyl)phenol,by GC-MS/MS.The sample was extracted by 2-propanol,cleaned up,and then determined with GC-MS/MS.When the target compounds' concentration is at 0.5 μg/g level,the recovery is in the range of 86.8%~109.7%,the LOD is at 10-8level,and the RSD is <8%.The method meets the requirements of real sample analysis. |
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| Keywords: | GC-MS/MS preservatives cosmetics |
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