| 4,4’-二氟苯偶酰的合成研究 |
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| 引用本文： | 方永勤,温迎雨.4,4’-二氟苯偶酰的合成研究[J].化学世界,2013,54(2):114-117. |
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| 作者姓名： | 方永勤 温迎雨 |
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| 作者单位： | 常州大学设计研究院,江苏常州,213164 |
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| 摘 要： | 以对氟苯甲醛为原料,3-丙基-4-甲基-5-羟乙基噻唑溴盐为催化剂,FeCl3/CuSO4/NaNO3为氧化剂,一锅法合成4,4’-二氟苯偶酰。考察了不同助催化剂及用量、催化剂用量、反应温度对反应收率的影响,得到较优工艺条件:三乙胺为辅助催化剂,m(对氟苯甲醛)∶m(催化剂)∶m(三乙胺)=100∶6∶14,反应温度90℃,总收率73.3%,产品结构经1 H NMR,IR确认。
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| 关 键 词： | 4 4’-二氟苯偶酰 噻唑盐 安息香缩合 氧化 |
Synthesis of 4,4 '-Difluorobenzil |
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| FANG Yong-qin,WEN Ying-yu.Synthesis of 4,4 '-Difluorobenzil[J].Chemical World,2013,54(2):114-117. |
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| Authors: | FANG Yong-qin WEN Ying-yu |
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| Affiliation: | (Design & Research Institute,Changzhou University,Jiangsu Changzhou 213164,China) |
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| Abstract: | 4,4'-Difluorobenzil was synthesized by one-pot procedure using 5-(2-hydroxyethyl)-4-methyl-3-propylthiazol-3-ium bromide as catalyst and FeCl3/CuSO4/NaNO3 as oxidant.The effects of different cocatalyst,amount of cocatalyst,amount of catalyst and reaction temperature on reaction yield were investigated.The optimum reaction conditions were as follows: triethylamine was the cocatalyst,the mass ratio of p-fluorobenzaldehyde,catalyst and triethylamine was 100∶6∶14,the reaction temperature was 90℃.The total yield was 73.3%.The structure of the target product was confirmed by 1H NMR and IR spectroscopy. |
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| Keywords: | 4 4'-difluorobenzil thiazolium salt benzoin condensation oxidation |
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