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| 脂肪酶催化合成D-异抗坏血酸月桂酸酯 | |
| 引用本文： | 张小兰,祝显虹,郑大贵,余泗莲.脂肪酶催化合成D-异抗坏血酸月桂酸酯[J].化学世界,2013,54(5):293-296,300. |
| 作者姓名： | 张小兰 祝显虹 郑大贵 余泗莲 |
| 作者单位： | 1. 上饶师范学院江西省普通高校应用有机化学重点实验室,江西上饶,334001 2. 南昌大学化学系,江西南昌,330031 3. 百勤异VC钠有限公司,江西德兴,334221 |
| 基金项目： | 江西省普通高校重点实验室科技计划项目，江西省科技条件平台建设项目 |
| 摘 要： | 用固定化脂肪酶Lipozyme 435作催化剂,由D-异抗坏血酸和月桂酸合成D-异抗坏血酸月桂酸酯。考察了反应温度、反应溶剂、反应物配比、酶用量、反应时间、月桂酸浓度、分子筛用量、摇床转速对产物收率的影响。结果表明,以20mL叔戊醇为反应溶剂、0.10g脂肪酶为催化剂、2.0g 4A分子筛为脱水剂,在55℃、170r/min转速的恒温摇床中,0.88g D-异抗坏血酸和2.50g月桂酸反应36h,产物收率68%。产物结构经IR、1H NMR、13C NMR和MS表征。 |
| 关 键 词： | 脂肪酶 D-异抗坏血酸 月桂酸 D-异抗坏血酸月桂酸酯 |
Lipase-catalyzed Synthesis of D-Isoascorbyl Laurate |
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| ZHANG Xiao-lan,ZHU Xian-hong,ZHENG Da-gui,YU Si-lian.Lipase-catalyzed Synthesis of D-Isoascorbyl Laurate[J].Chemical World,2013,54(5):293-296,300. | |
| Authors: | ZHANG Xiao-lan ZHU Xian-hong ZHENG Da-gui YU Si-lian |
| Affiliation: | 1.Key Laboratory of Applied Organic Chemistry,Higher Institutions of Jiangxi Province,Shangrao Normal University,Jiangxi Shangrao 334001,China; 2.Chemistry Department,Nanchang University,Jiangxi Nanchang 330031,China; 3.Parchn Sodium Isovitamin C Co.Ltd.,Jiangxi Dexing 334221,China) |
| Abstract: | The lipase-catalyzed synthesis of D-isoascorbyl laurate via direct esterification of D-isoascorbic acid and lauric acid was studied.The factors affecting synthetic reaction,such as reaction temperature,the type of organic solvent,the molar ratio of reactants,the amount of lipase,reaction time,the concentration of lauric acid,the amount of molecular sieves and the shaker speed,were investigated.It was found that when the reaction of 0.88 g D-isoascorbic acid and 2.50 g lauric acid was catalyzed by 0.10 g lipozyme 435 in 20 mL tert-amyl alcohol with 2.0 g 4A molecular sieves added and shaker speed of 170 r/min for 36h at 55℃,the yield of D-isoascorbyl laurate could reach 68%.The product structure was confirmed by IR,1H NMR,13C NMR and MS. |
| Keywords: | lipase D-isoascorbic acid lauric acid D-isoascorbyl laurate |
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