| 诺氟沙星合成方法的改进 |
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| 引用本文： | 胡国强,董秀丽.诺氟沙星合成方法的改进[J].化学试剂,2007,29(9):575-576. |
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| 作者姓名： | 胡国强 董秀丽 |
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| 作者单位： | 河南大学,药物研究所,河南,开封,475001;河南确山县人民医院,河南,确山,463200 |
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| 摘 要： | 1-乙基-6-氟-7-氯-1,4-二氢-4-氧代喹啉-3-羧酸与哌嗪在聚乙二醇催化下反应,以高收率得到诺氟沙星。
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| 关 键 词： | 氟喹诺酮类抗菌剂 诺氟沙星 催化剂 合成 |
| 文章编号： | 0258-3283（2007）09-0575-02 |
| 修稿时间： | 2007-02-12 |
An improved method for synthesis of norfloxacin |
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| HU Guo-qiang,DONG Xiu-li.An improved method for synthesis of norfloxacin[J].Chemical Reagents,2007,29(9):575-576. |
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| Authors: | HU Guo-qiang DONG Xiu-li |
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| Abstract: | An improved method for synthesis of quinolone antibacterial agent norfloxacin from 1-ethyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid via condensation with piperazine in the presence of the catalyst PEG-1000 was described,resulting in a good yield of the target product. |
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| Keywords: | quinolone antibacterial agent norfloxacin catalyst synthesis |
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