| 3-氨基-2,2-二甲基丙酰胺的合成 |
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| 引用本文： | 罗瑾,彭小海,钟敏,尤庆亮,喻宗沅. 3-氨基-2,2-二甲基丙酰胺的合成[J]. 化学与生物工程, 2011, 0(9): 49-51. DOI: 10.3969/j.issn.1672-5425.2011.09.013 |
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| 作者姓名： | 罗瑾 彭小海 钟敏 尤庆亮 喻宗沅 |
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| 作者单位： | 湖北省化学研究院,湖北武汉,430074 |
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| 摘 要： | 以氰乙酸甲酯为原料经双甲基化、氨解、还原三步合成了3-氨基-2,2-二甲基丙酰胺.在双甲基化步骤中以绿色环保的碳酸二甲酯作为甲基化试剂进行反应,氨解、还原反应在高压釜中同时进行,中间产物不经处理,反应总收率由氨解和还原分别单独进行的80％左右提高到92％.
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| 关 键 词： | 碳酸二甲酯 双甲基化 氨解 还原 2,2-二甲基氰乙酸甲酯 3-氨基-2,2-二甲基丙酰胺 |
Synthesis of 3-Amino-2,2-dimethyl-propionamide |
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| LUO Jin,PENG Xiao-hai,ZHONG Min,YOU Qing-liang,YU Zong-yuan. Synthesis of 3-Amino-2,2-dimethyl-propionamide[J]. Chemistry & Bioengineering, 2011, 0(9): 49-51. DOI: 10.3969/j.issn.1672-5425.2011.09.013 |
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| Authors: | LUO Jin PENG Xiao-hai ZHONG Min YOU Qing-liang YU Zong-yuan |
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| Affiliation: | LUO Jin,PENG Xiao-hai,ZHONG Min,YOU Qing-liang,YU Zong-yuan(Hubei Research Institute of Chemistry,Wuhan 430074,China) |
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| Abstract: | With methyl cyanoacetate as raw material,3-amino-2,2-dimethyl-propionamide was synthesized through double methylation,ammonolysis and reduction.Harmless dimethyl carbonate(DMC) acted as methylating agent in the methylation reaction.Ammonolysis and reduction were carried out together in the high-pressure autoclave,and the total yield reached 92%,which increased obviously from the 80% obtained when ammonolysis and reduction was done separately. |
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| Keywords: | dimethyl carbonate double-methylation ammonolysis reduction 2 2-dimethyl methyl cyanoacetate 3-amino-2 2-dimethyl-propionamide |
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