| 6-硝基-4-二甲氨基甲基-5-羟基-1-甲基-2-苯硫甲基-1H-吲哚-3-羧酸乙酯的合成 |
| |
| 引用本文： | 宋萍,赵静国,李桂杰.6-硝基-4-二甲氨基甲基-5-羟基-1-甲基-2-苯硫甲基-1H-吲哚-3-羧酸乙酯的合成[J].化学与生物工程,2011,28(8):57-59. |
| |
| 作者姓名： | 宋萍 赵静国 李桂杰 |
| |
| 作者单位： | 武汉工业学院生物与制药工程学院,湖北武汉,430023 |
| |
| 摘 要： | 以对苯醌和3-(甲基氨基)-2-丁烯酸乙酯为起始原料,经Nenitzescu反应、乙酰化、硝化、溴代、缩合、Mannich反应得到一个新化合物6-硝基-4-二甲氨基甲基-5-羟基-1-甲基-2-苯硫甲基-1H-吲哚-3-羧酸乙酯,总产率19.3％.反应中间产物和目标产物结构采用1 HNMR和质谱确认.
|
| 关 键 词： | 6-硝基-4-二甲氨基甲基-5-羟基-1-甲基-2-苯硫甲基-1H-吲哚-3-羧酸乙酯 阿比朵尔 Nenitzescu反应 合成 |
Synthesis of Ethyl 4-Dimethylaminomethyl-5-hydroxy-1-methyl-6-nitro-2-phenylthiomethylindole-3-carboxylate |
| |
| SONG Ping,ZHAO Jing-guo,LI Gui-jie.Synthesis of Ethyl 4-Dimethylaminomethyl-5-hydroxy-1-methyl-6-nitro-2-phenylthiomethylindole-3-carboxylate[J].Chemistry & Bioengineering,2011,28(8):57-59. |
| |
| Authors: | SONG Ping ZHAO Jing-guo LI Gui-jie |
| |
| Affiliation: | SONG Ping,ZHAO Jing-guo,LI Gui-jie(College of Biological and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan 430023,China) |
| |
| Abstract: | A novel compound ethyl 4-dimethylaminomethyl-5-hydroxy-1-methyl-6-nitro-2-phenylthiomethlindole-3-carboxylate was synthesized by using 1,4-benzoquinone and ethyl 3-(methylamino)-2-butenoate as raw materials,and via Nenitzescu reaction,O-acylation,nitration,bromination,condensation and Mannich reaction with an overall yield of 19.3%.The structures of synthesized intermediates and target compound were confirmed by 1HNMR and MS. |
| |
| Keywords: | ethyl 4-dimethylaminomethyl-5-hydroxy-1-methyl-6-nitro-2-phenylthiomethylindole-3-carboxylate arbidol Nenitzescu reaction synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
