| 氨茶碱在大鼠体内的药代动力学研究 |
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| 引用本文： | 周明祎,陈秋晨,付婴子,姜雨,魏敏杰. 氨茶碱在大鼠体内的药代动力学研究[J]. 化学与生物工程, 2011, 28(10): 72-74. DOI: 10.3969/j.issn.1672-5425.2011.10.019 |
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| 作者姓名： | 周明祎 陈秋晨 付婴子 姜雨 魏敏杰 |
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| 作者单位： | 1. 中国医科大学,辽宁沈阳,110001
2. 中国医科大学药学院,辽宁沈阳,110001 |
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| 摘 要： | 用高效液相色谱法研究氨茶碱在大鼠体内的药代动力学.色谱柱为Hypersil BDS C18 (4.6 mm×200mm,5 μm),流动相为甲醇—水(24 ∶ 76),检测波长为274 nm.结果表明,大鼠灌胃给予氨茶碱后,其代谢符合二室模型；由统计矩参数表示的主要药代动力学参数如下:tmax=(1.083士0.195...
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| 关 键 词： | 高效液相色谱法 氨茶碱 茶碱 药代动力学 |
Study on Pharmacokinetics of Aminophylline in Rat |
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| ZHOU Ming-yi,CHEN Qiu-chen,FU Ying-zi,JIANG Yu,WEI Min-jie. Study on Pharmacokinetics of Aminophylline in Rat[J]. Chemistry & Bioengineering, 2011, 28(10): 72-74. DOI: 10.3969/j.issn.1672-5425.2011.10.019 |
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| Authors: | ZHOU Ming-yi CHEN Qiu-chen FU Ying-zi JIANG Yu WEI Min-jie |
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| Affiliation: | ZHOU Ming-yi1,CHEN Qiu-chen2,FU Ying-zi2,JIANG Yu2,WEI Min-jie2(1.China Medical University,Shenyang 110001,China,2.School of Pharmacy,China Medical University,China) |
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| Abstract: | The pharmacokinetic process about the concentration in rat plasma of aminophylline was investigated by HPLC.HPLC Analysis was carried out by using Hypersil BDS C18 column(4.6 mm×200 mm,5 μm)and methanol-water(24∶76) as the mobile phase,and the UV detection wavelength was 274 nm.Results showed that,the concentration-time data of aminophylline were all in accordance with an open two-compartment model.The main pharmacokinetics parameters were as follows:tmax was(1.083±0.195)h,cmax was(74.349±7.599)mg·L-1,t1/2 was(3.283±0.631)h,AUC0~∞ was(457.664±61.173)mg·L-1·h-1,MRT0~∞ was(5.265±0.610)h,CL was(0.046±0.007)L·kg-1·h-1.The method was simple,accurate,highly sensitive and reproducible.It was a good reference for pharmacokinetics of aminophylline in human bodies. |
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| Keywords: | HPLC aminophylline theophylline pharmacokinetics |
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