含锶磷酸钙骨水泥的制备及性能研究

通过混合磷酸四钙、磷酸氢钙、磷酸氢锶及稀磷酸制备了一种含锶磷酸钙骨水泥(Sr-CPC),研究了水泥固/液比、含锶量及仿生浸泡时间对其结构组态及抗压强度的影响.结果表明,不同组分的CPC在调和浆体时均存在最佳固/液比,且对应的凝结时间适合临床手术要求;Sr-CPC试样在模拟体液(SBF)中浸泡24h后固化产物为含锶缺钙羟基磷灰石;适量锶的加入及较短时间仿生浸泡均可显著改善Sr-CPC固化体的抗压强度,并且浸泡过程对固化体抗压强度的影响主要体现在其微观结构的变化.

Preparation and Property of Sr-Containing Calcium Phophate Cement

A noval Sr-containing calcium phosphate cement (Sr-CPC) was synthesized by mixing tetracalcium phosphate, dicalcium phosphate anhydrous, strontium hydrogen phosphate and phosphate acid. The effects of weight ratio of cement powder to liquid (P/L), the content of Sr and immersion time of samples in simulated body fluid (SBF) on their compressive strength and microstructure of samples were investigated. The results show that there exists an optimum P/L ratio for each cement paste with an excellent workability and setting times, and the setting times of the cement paste obtained at its optimum P/L ratio meet the clinical demands. After immersion in SBF for 24h, the Sr-CPC has transformed into Sr-containing deficient-calcium apatites. The content of Sr and immersion time of samples in SBF have distinct effects on the compressive strength (CS) of the cement hardened bodies. A proper content of Sr and a shorter immersion time are beneficial to improving the CS, and the variation of macrostructure plays a significant role in the CS of the hardened bodies during immersion in SBF.