| 合成N-甲基-4-哌啶酮的新工艺 |
| |
| 引用本文： | 丁敬敏,陈绘如,陈升,张文雯,陈闻起. 合成N-甲基-4-哌啶酮的新工艺[J]. 化工中间体, 2008, 4(9): 21-24 |
| |
| 作者姓名： | 丁敬敏 陈绘如 陈升 张文雯 陈闻起 |
| |
| 作者单位： | 1. 常州工程职业技术学院应用化学技术系,江苏常州,213164
2. 福建建材工业学校,福建福州,350002 |
| |
| 摘 要： | 以甲胺溶液和丙烯酸乙酯为原料，经过加成、环合、成盐脱羧合成N-甲基-4-哌啶酮。对合成工艺进行了优化和改进，确定了较佳加成反应温度为50％，加成溶剂为三乙胺，缩合反应双酯与钠的较佳摩尔配比为1：1．4。产品总收率由文献值的53％提高到59．7％（以丙烯酸乙酯计算）。目标化合物经核磁共振分析确认。
|
| 关 键 词： | 甲胺 丙烯酸乙酯 N-甲基-4-哌啶酮 |
The New Synthesis Process of N-methyl-4-piperidone |
| |
| Ding Jingmin,Chen Hui-ru,Chen Sheng,Zhang Wenwen,Chen Wenqi. The New Synthesis Process of N-methyl-4-piperidone[J]. , 2008, 4(9): 21-24 |
| |
| Authors: | Ding Jingmin Chen Hui-ru Chen Sheng Zhang Wenwen Chen Wenqi |
| |
| Affiliation: | Ding Jingmin, Chen Hui-ru, Chen Sheng, Zhang Wenwen, Chen Wenqi (1.Department of Applied Chemistry Technology, Changzhou Institute of Engineering Technology, Changzhou Jiangsu 213164 ; 2.FuJian Building Material Institute of Technology, Fuzhou Fujian 350002) |
| |
| Abstract: | N-methyl-4-piperidone was synthesized with methylamine and ethyl acrylate as raw materials via a series of addition, dieckmann condensation and hydrolysis decarboxylafion reactions The synthetic process and after-treatment were optimized and improved. The total yield of this procedure was increased from 53% to 59.7%. And the product was identified by IHNMR . |
| |
| Keywords: | methylamine ethyl acryate N-methyl-4-piperidone |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
