Pathogenesis of dengue virus diseases: missing pieces in the jigsaw |
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Authors: | H Bielefeldt-Ohmann |
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Affiliation: | Centre for Molecular Biotechnology (Arbovirology Group), School of Life Science, Queensland University of Technology, Brisbane, Australia. helle@biosci.ug.edu.au |
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Abstract: | The mechanisms involved in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome remain unresolved. Antibody-dependent enhancement of infection has long been thought to play a central role; however, this remains unverified. The alternative hypothesis that virus variation, virulence and dynamics may account for severe dengue disease, particularly in children, should be considered. |
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