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Statistical significance testing and clinical trials.
Authors:Krause   Merton S.
Abstract:The efficacy of treatments is better expressed for clinical purposes in terms of these treatments' outcome distributions and their overlapping rather than in terms of the statistical significance of these distributions' mean differences, because clinical practice is primarily concerned with the outcome of each individual client rather than with the mean of the variety of outcomes in any group of clients. Reports of the obtained outcome distributions for the comparison groups of all competently designed and executed randomized clinical trials should be publicly available no matter what the statistical significance of the mean differences among these groups, because all of these studies' outcome distributions provide clinically useful information about the efficacy of the treatments compared. (PsycINFO Database Record (c) 2011 APA, all rights reserved)
Keywords:mean outcome difference   null hypothesis significance test   outcome distribution   outcome overlaps   publication decisions   randomized clinical trial
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