4,4-二甲基-1-(4-氯苯基)-3-戊酮的合成

以对氯苯甲醛和频哪酮为原料,经缩合、氢化合成4,4-二甲基-1-(4-氯苯基)-3-戊酮.工艺选择了强碱性离子交换树脂为碱性催化剂以及采用CO2中和体系中的碱性物质,使4,4-二甲基-1-(4-对氯苯基)-1-戊烯-3-酮的收率达到98.3%,纯度达到97.4%;氢化反应中通过调节反应体系的pH值及使用添加剂如N,N-二甲基甲酰胺可减少副产物脱氯产物的产生,提高了目标产物的含量和收率,分别达到了98.7%,收率达到98%以上.该工艺各项经济技术指标均超过文献水平.

Synthesis of 1-(4-chloro-phenyl)-4,4-dimethyl-pentan-3-one

Using 4-chlorophenyl aldehyde and 3,3-Dimethyl-2butanone as raw materials,1-(4-Chloro-phenyl)-4,4-dimethyl-pentan-3-one was synthesized by condensation and hydrogenation processes.The yield of 1-(4-Chloro-phenyl)-4,4-dimethyl-pent-1-en-3-one can be reached 98.3% with the purity of 97.4%(GC) by using strongly basic ion exchange resin and CO2.By regulating value of pH and using flux such as N,N-dimethyl formamide,the dechloridizing byproduct was reduced,and the yield of 1-(4-Chloro-phenyl)-4,4dimethyl-pentan-3-one can be reached 98% with the purity 98.7%(GC).Economic and technical indices of the above synthetic method are more favorable than those previously reported.