| 超临界流体结晶分离黄芩苷的工艺研究 |
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| 引用本文： | 张爽,韩冰.超临界流体结晶分离黄芩苷的工艺研究[J].安徽化工,2011,37(6):10-12. |
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| 作者姓名： | 张爽 韩冰 |
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| 作者单位： | 南京市产品质量监督检验院,江苏南京,210028;南京市产品质量监督检验院,江苏南京210028;北京大学地球与空间科学学院,北京100871 |
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| 基金项目： | 国家“十一五”科技支撑课题(项目编号:2006BAI06A14) |
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| 摘 要： | 采用超临界流体结晶法进行了黄芩苷的结晶纯化研究。重点研究了温度、压力、时间对结晶纯度的影响。正交实验结果表明：影响萃取的主次因素为：A（温度）〉C（时间）〉B（压力）；较佳工艺参数：温度为55％，压力为16MPa，萃取60min，获得黄芩苷的纯度高达94．1％。
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| 关 键 词： | 黄芩苷 超临界流体抗溶剂结晶 正交实验 |
Study on the Technology of Supercritical Fluid Crystallizing Baicalin |
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| ZHANG Shuang,HAN Bing.Study on the Technology of Supercritical Fluid Crystallizing Baicalin[J].Anhui Chemical Industry,2011,37(6):10-12. |
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| Authors: | ZHANG Shuang HAN Bing |
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| Affiliation: | (1.Nanjing Institute of Supervision & Testing on Product Quality,Nanjing 210028,China; 2.School of Earth and Space Sciences,Peking University,Beijing 100871,China) |
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| Abstract: | The article introduced the technology of supercritical fluid crystallizing Baicalin,putting emphasis on effects of temperature,pressure and time on the purity.The optimum technology parameter was investigated by the orthogonal design: the factors influencing the purity were as follows:A-temperature > C-time > B-pressure,the optimum crystallization conditions were: temperature of 55℃,pressure of 16MPa and time of 60min,the maximum purity of Baicalin is up to 94.15%. |
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| Keywords: | Baicalin supercritical fluid antisolvent crystallization orthogonal design |
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