| 阿魏酰哌嗪盐酸盐的合成 |
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| 引用本文： | 肖幼安,黄广,何黎琴,王效山. 阿魏酰哌嗪盐酸盐的合成[J]. 安徽化工, 2011, 37(6): 25-26,30. DOI: 10.3969/j.issn.1008-553X.2011.06.009 |
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| 作者姓名： | 肖幼安 黄广 何黎琴 王效山 |
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| 作者单位： | 安徽中医学院,安徽省现代中药重点实验室,安徽合肥230031;安徽中医学院,安徽省现代中药重点实验室,安徽合肥230031;安徽中医学院,安徽省现代中药重点实验室,安徽合肥230031;安徽中医学院,安徽省现代中药重点实验室,安徽合肥230031 |
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| 摘 要： | 目的：合成阿魏酰哌嗪盐酸盐。方法：以阿魏酸为起始原料，对羟基进行乙酰化保护，得到乙酰阿魏酸，经酰氯化后与哌嗪反应得到单取代哌嗪衍生物，除去乙酰基得到目标物。结果与结论：合成得到了阿魏酰哌嗪，目标化合物通过IR,1HNMR和MS等确证，产率为56．9％。
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| 关 键 词： | 阿魏酸 哌嗪 阿魏酰哌嗪盐酸盐 |
Synthesis of 3-(4-Hydroxy-3-methoxy-phenyl)-1 -piperazin-1-yl- propenone Hydrochloride |
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| XIAO You-an,HUANG Guang,HE Li-qin,WANG Xiao-shan. Synthesis of 3-(4-Hydroxy-3-methoxy-phenyl)-1 -piperazin-1-yl- propenone Hydrochloride[J]. Anhui Chemical Industry, 2011, 37(6): 25-26,30. DOI: 10.3969/j.issn.1008-553X.2011.06.009 |
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| Authors: | XIAO You-an HUANG Guang HE Li-qin WANG Xiao-shan |
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| Affiliation: | (Anhui College of Traditional Chinese Medicine,Anhui Modern Traditional Chinese Medicinal Key Laboratory,Hefei 230031,China) |
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| Abstract: | Objective:Synthesis of 3-(4-hydroxy-3-methoxy-phenyl)-1-piperazin-1-yl-propenone hydrochloride.Methods:The synthesis involved ferulic acid acetylation protection,then reacted with piperazine to obtain monosubstituted piperazine derivatives,then deacetylase to obtain target product.Results and conclusions:The chemical structure of 3-(4-hydroxy-3-methoxy-phenyl)-1-piperazin-1-yl-propenone hydrochloride was confirmed by IR,1HNMR and MS.The yield was over 56.9%. |
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| Keywords: | ferulic acid piperazine 3-(4-hydroxy-3-methoxy-phenyl)-1-piperazin-1-yl-propenone hydrochloride |
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