| 2-氨基-5-甲基吡啶重氮化合成2-氯-5-甲基吡啶的方法研究 |
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| 引用本文： | 毛逢银,孙明炳,何静,邱露,牛鑫超. 2-氨基-5-甲基吡啶重氮化合成2-氯-5-甲基吡啶的方法研究[J]. 精细化工中间体, 2010, 40(5): 23-26 |
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| 作者姓名： | 毛逢银 孙明炳 何静 邱露 牛鑫超 |
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| 作者单位： | 四川理工学院,四川自贡643000 |
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| 摘 要： | 以2-氨基-5-甲基吡啶为原料,经重氮化、氯代热解反应制得了2-氯-5-甲基吡啶,研究了浓盐酸用量、亚硝酸钠用量、氯代温度、氯代时间、不同氯代剂对2-氯-5-甲基吡啶收率的影响。优化工艺条件为:氯化亚铜为催化剂,n(2-氨基-5-甲基吡啶)∶n(盐酸)=1∶3、n(2-氨基-5-甲基吡啶)∶n(亚硝酸钠)=1∶1.1、重氮化温度为0～5℃,氯代温度45℃、氯代时间8 h、稀盐酸为氯代剂,优化条件下产品的收率为74.76%。
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| 关 键 词： | 2-氯-5-甲基吡啶 2-氨基-5-甲基吡啶 重氮化 氯代 |
Study on Synthesis of 2-Chloro-5-methylpyridine |
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| MAO Feng-yin,SUN Ming-bing,HE Jing,QIU Lu,NIU Xin-chao. Study on Synthesis of 2-Chloro-5-methylpyridine[J]. Fine Chemical Intermediates, 2010, 40(5): 23-26 |
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| Authors: | MAO Feng-yin SUN Ming-bing HE Jing QIU Lu NIU Xin-chao |
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| Affiliation: | (College of Material and Chemical Engineering,Sichuan Institute of Technology,Zigong 643000,China) |
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| Abstract: | 2-Chloro-5-methylpyridine was prepared from 2-amino-5-methylpyridine in 74.8% yield by the reaction of diazotization and chlorinated pyrolysis under catalysis of cuprous chloride.The optimum reaction conditions were achieved as follows： n（2-amino-5-methylpyridine）∶n（hydrochloric acid）=1∶3,n（2-amino-5-methylpyridine）∶n（sodium nitrite）=1∶1.1,diazotization temperature 0～5℃,chlorination at 45℃ / 8h. |
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| Keywords: | 2-chloro-5-methylpyridine 2-amino-5-methylpyridine diazotization chlorination |
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