Baeyer-Villiger氧化反应催化体系的研究新进展

对近几年Baeyer-Villiger氧化反应中常用的催化剂及其作用机理的研究进行了综述,按催化剂的作用特点将其分为6大类:酸催化剂、过渡金属氧化物催化剂、水滑石类催化剂、掺杂过渡金属离子的分子筛催化剂、微生物酶催 化剂及过渡金属配合物催化剂,并指出了它们的优缺点。Baeyer-Villiger反应是一类将开链酮或环酮转化成相应的 酯或内酯的氧化反应,从总的发展方向上看,这类反应催化剂作用的高效性、反应的原子经济性以及在不对称合成中的应用是特别值得关注的几个方面。

Recent Progress in Baeyer-Villiger Oxidation Catalysts

cent progress in catalysts and mechanism of Baeyer-Villiger oxidation process was reviewed. According to specific functions,the catalysts were sorted into six types including acids, transition metal oxides, hydrotalcites,zeolites grafted with transition metal ion, enzyme and transition metal complexes. The pros and cons of each type were stated. Baeyer - Villiger oxidation is a reaction to open ketone/cycloketone chain and obtain corresponding ester/lactone. More attention should be paid in future to efficiency of catalysts, atom economy and their application in asymmetry synthesis.