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Live cell luminescence imaging as a function of delivery mechanism |
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| Authors: | Tian Xiaohe Gill Martin R Cantón Irene Thomas Jim A Battaglia Giuseppe |
| Affiliation: | Department of Biomedical Science, The University of Sheffield, Sheffield S10 7TN, UK. |
| Abstract: | Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH-sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties. |
| Keywords: | bioinorganic chemistry cellular imaging confocal microscopy intercellular delivery polymersomes ruthenium |
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