| 上转换荧光实时监测近红外实现肿瘤热疗 |
| |
| 引用本文： | 魏言春,吴宝艳,杨利勇,邢达. 上转换荧光实时监测近红外实现肿瘤热疗[J]. 中国激光, 2010, 0(11) |
| |
| 作者姓名： | 魏言春 吴宝艳 杨利勇 邢达 |
| |
| 作者单位： | 华南师范大学生物光子学研究院激光生命科学研究所激光生命科学教育部重点实验室; |
| |
| 基金项目： | 国家973计划(2010CB732602); 国家自然科学基金(30800261,30870658); 教育部“长江学者与创新团队计划”创新团队项目(IRT0829)资助课题 |
| |
| 摘 要： | 以激光进行的高温疗法称激光加热疗法,已成为肿瘤热疗的一种新的有效手段。主要使用近红外激光,采用直接照射或插入光纤的方法进行治疗。但应用时由于近红外波段激光对组织的穿透有限,热效应被局限在一个小的体积内,不同肿瘤组织光穿透情况又有很大差异,治疗的范围难以把握。另外,热疗时,难以区分肿瘤体和正常组织的边界,照射不当容易造成周围正常组织的伤害,因此实时地监测导向近红外光成为激光热疗的关键。研究表明运用上转换纳米探针[Yb/Er(NaYF4∶Yb,Er)]靶向定位到肿瘤,在980 nm近红外光的激发下可实现激光加热的同时进行上转换荧光的监测,从而确定照射的范围、分布、剂量以及肿瘤边界,最终达到导向热疗实现精确治疗肿瘤的目的。
|
| 关 键 词： | 医用光学 肿瘤 激光热疗 上转换荧光 靶向 |
Upconversion Fluorescence Monitoring Near-Infrared During Tumor Photothermal Therapy |
| |
| Wei Yanchun Wu Baoyan Yang Liyong Xing Da. Upconversion Fluorescence Monitoring Near-Infrared During Tumor Photothermal Therapy[J]. Chinese Journal of Lasers, 2010, 0(11) |
| |
| Authors: | Wei Yanchun Wu Baoyan Yang Liyong Xing Da |
| |
| Affiliation: | Wei Yanchun Wu Baoyan Yang Liyong Xing Da (Key Laboratory of Laser Life Science & Institute of Laser Life Science,Ministry of Education,College of Biophotonics,South China Normal University,Guangzhou,Guangdong 510631,China) |
| |
| Abstract: | The photothermal therapy which mainly uses near-infrared laser to heat tissue has become a new validated method for tumor treatment through direct surface irradiating or inserting light fibers in tumor.The near-infrared light transfer in tissue is limit and the thermal effect occurs only in a small volume during treatment.Thus the treating extent is difficult to control.Otherwise,it is difficult to distinguish the boundary of tumor and normal tissue in photothermal therapy.Improper heating will hurt the nor... |
| |
| Keywords: | medical optics tumor laser thermal therapy upconversion fluorescence target |
| 本文献已被 CNKI 等数据库收录！ |
|
