Plasmodium falciparum- and merozoite surface protein 1-specific antibody isotype balance in immune Senegalese adults |
| |
Authors: | CM Nguer TO Diallo A Diouf A Tall A Dieye R Perraut O Garraud |
| |
Affiliation: | Laboratoire d'Immunologie, Institut Pasteur, Dakar, Sénégal. |
| |
Abstract: | This study shows markedly different isotype distributions of antibodies to asexual blood stages of Plasmodium falciparum and to merozoite surface protein 1 in clinically immune Senegalese adults depending on the study site. The relationships between immunoglobulin M (IgM) and IgG and between IgG3 and IgG1 antibodies differed in settings where transmission is perennial compared to settings where it is seasonal. This suggests a role for antibody class and/or subclass production and utilization in the regulation of protective immunity to such antigens. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |