Workshop Report: Modeling the Molecular Mechanism of Bacterial Spore Germination and Elucidating Reasons for Germination Heterogeneity |
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| Authors: | Karl J. Indest Wallace G. Buchholz Jim R. Faeder Peter Setlow |
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| Affiliation: | Author Indest is with Environmental Processes Branch, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Rd., Vicksburg, MS 39180, U.S.A. Author Buchholz is with the Life Sciences Div., U.S. Army Research Office, 4300 S. Miami Blvd, Durham, NC 27703, U.S.A. Author Faeder is with Dept. of Computational Biology, Univ. of Pittsburgh School of Medicine, Pittsburgh, PA 15260, U.S.A. Author Setlow is with Dept. of Molecular, Microbial and Structural Biology, Univ. of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, U.S.A. Direct inquiries to author Buchholz (E-mail: ). |
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| Abstract: | ABSTRACT: Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germination were presented and evaluated. As a result of these interactions, future research directions were defined, the outcome of which should result in a robust model to help define the molecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores. |
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| Keywords: | bacterial spores microbial survival modeling |
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