Addition of long-chain polyunsaturated fatty acids to formula for very low birth weight infants |
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| Authors: | M T Clandinin M L Garg A Parrott J Van Aerde A Hervada E Lien |
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| Affiliation: | (1) Nutrition and Metabolism Research Group, University of Alberta, 533 Newton Research Bldg., T6G 2C2 Edmonton, Alberta, Canada;(2) Department of Foods and Nutrition, University of Alberta, 533 Newton Research Bldg., T6G 2C2 Edmonton, Alberta, Canada;(3) Department of Medicine, University of Alberta, 533 Newton Research Bldg., T6G 2C2 Edmonton, Alberta, Canada;(4) Department of Pediatrics, University of Alberta, 533 Newton Research Bldg., T6G 2C2 Edmonton, Alberta, Canada;(5) Wyeth-Ayerst Research, 533 Newton Research Bldg., 19101-1245 Radnor, Pennsylvania, Edmonton, Alberta, Canada, T6G 2C2 |
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| Abstract: | Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed “preemie”
SMA-24 formula, “preemie” SMA-24 formula manufactured to contain C20 and C22 ω6 and ω3 fatty acids (LCPE-SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first
week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24
had a high content of 18∶2ω6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of C20 and C22 ω6 and ω3 fatty acids to be similar to levels of C20 and C22 ω6 and ω3 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24.
Feeding LCPE-SMA or EBM results in a balanced incorporation of C20 and C22 ω6 and ω3 fatty acids into phospholipids derived from the liver or perhaps the small intestine.
Based on a paper presented at the Symposium on Milk Lipids held at the 1990 AOCS Annual Meeting, Baltimore, MD, April 1990. |
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